Nanostructure of mouse otoconia
نویسندگان
چکیده
منابع مشابه
Destructive properties of formalin on human otoconia
Background: Formalin is a preservation media for human tissues. Since the chemical structure is known, interaction in tissue preparation can be expected, that affect otoconia morphology. To investigate the suitability of the preservation media using formalin and ethanol for human otoconia in order to prove a shortterm and long-term storage after sampling. Methods: Intact and degenerate human ot...
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The vestibular system contributes to the performance of various spatial memory tasks, but few studies have attempted to disambiguate the roles of the semicircular canals and otolith organs in this performance. This study tested the otolithic contribution to spatial working and reference memory by evaluating the performance of otoconia-deficient tilted mice on a radial arm maze and a Barnes maze...
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The vestibule of the inner ear senses head motion for spatial orientation and bodily balance. In vertebrates, the vestibular system consists of three fluid filled semicircular canals, which detect rotational acceleration, and two gravity receptor organs, the utricle and saccule, which respond to linear acceleration and gravity (Figure 1). The utricle and saccule are also referred to as the otol...
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Human otoconia provide mechanical stimuli to deflect hair cells of the vestibular sensory epithelium for purposes of detecting linear acceleration and head tilts. During lifetime, the volume and number of otoconia are gradually reduced. In a process of degeneration morphological changes occur. Structural changes in human otoconia are assumed to cause vertigo and balance disorders such as benign...
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Otoconia are bio-crystals anchored to the macular sensory epithelium of the utricle and saccule in the inner ear for motion sensing and bodily balance. Otoconia dislocation, degeneration and ectopic calcification can have detrimental effects on balance and vertigo/dizziness, yet the mechanism underlying otoconia formation is not fully understood. In this study, we show that selected matrix comp...
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ژورنال
عنوان ژورنال: Journal of Structural Biology
سال: 2020
ISSN: 1047-8477
DOI: 10.1016/j.jsb.2020.107489